The first and major step in genomic research that the scientific community hopes to achieve is invention of reliable and advanced technology that will enable completion of the Human Genome project. This is so that they can finally understand the complete genetic composition and function of the human being. Next would be to establish a reliable operation of public data repositories and address the issues the scientific community faces given the current overwhelming increase in genetic data output. This should include allowance of the submission of differentiated treatment of DNA sequences for archiving. If correct information on sequences is stored reliably and efficiently over the internet and scientists all over the world are able to access it, then this will lead to major contributions towards genomic research. Research focused on areas such as genomic sequences of key mammals, comprehensive collections of knockouts and knockdowns of all genes in selected animals to accelerate the development of models of disease, cohort populations for studies designed to identify genetic contributors to health and to assess the effect of individual gene variants on disease risk, reference sets of proteins from key species in various formats and reference sets of coding sequences from key species will be performed sooner than anticipated.
Improvements in genomic research has become important now more than ever considering the increase in numbers of infectious and non-infectious diseases. Therefore, all societies, including those in the less developed countries must be encouraged to invest in large-scale human genome variation studies in order to better understand genetic variants for all human races with possible regard to the environmental factors. As science continues to advance, scientists must also be encouraged to develop tools that are clinically applicable to genetic research such as risk prediction, diagnosis or therapeutic interventions. Growth in this area is critical for the understanding and eradication of non-communicable diseases because it will lead to identifying of rare and novel genetic variants associated with the diseases and their risk factors. It will also lead to development of genome-based strategies for early detection, diagnosis and treatment of various diseases. Identification of single nucleotide polymorphisms will also identify variations that contribute towards a person’s response towards certain drugs. This will contribute towards development of Pharmacogenetics (the field of science that deals with how genes affect a person’s response to drugs).
Lastly, exploring the ethical, legal and social issues that affect genomic research is also crucial. Steps should be taken to ensure that these issues do not present as obstacles towards significant developments in the area of genomics. Deriving meaningful knowledge of the human genome is the ultimate agenda in genomic research. Therefore, as we acknowledge the remarkable achievements in the field of genomic research such as the International HapMap project, ENCODE and Human Genome project, it is crucial to emphasize that a lot of information on genetic composition, gene expression and functions is still unknown and steps to help in advancement of this area of research are an absolute necessity.
admin January 16th, 2014
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